The blood supply of the orbit is mainly from the ophthalmic artery, a branch of the internal carotid artery; the infra-orbital artery, from the external carotid artery, also contributes blood to structures related to the orbital floor. The central artery of the retina, a branch of the ophthalmic artery arising inferior to the optic nerve, pierces the sheath of the optic nerve and runs within the nerve to the eyeball, emerging at the optic disc. Its branches spread over the internal surface of the retina. The terminal branches are end arteries (arterioles), which provide the only blood supply to the internal aspect of the retina.

The external aspect of the retina is also supplied by the capillary lamina of the choroid (choriocapillaris). Of the eight or so posterior ciliary arteries (also branches of the ophthalmic artery), six short posterior ciliary arteries directly supply the choroid, which nourishes the outer non-vascular layer of the retina. Two long posterior ciliary arteries, one on each side of the eyeball, pass between the sclera and the choroid to anastomose with the anterior ciliary arteries (continuations of the muscular branches of the ophthalmic artery to the rectus muscles) to supply the ciliary plexus.